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Mitochondrial permeability transition in rat hepatocytes after anoxia/reoxygenation: role of Ca(2+)-dependent mitochondrial formation of reactive oxygen species

Onset of the mitochondrial permeability transition (MPT) is the penultimate event leading to lethal cellular ischemia-reperfusion injury, but the mechanisms precipitating the MPT after reperfusion remain unclear. Here, we investigated the role of mitochondrial free Ca(2+) and reactive oxygen species...

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Autors principals: Kim, Jae-Sung, Wang, Jin-Hee, Lemasters, John J.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3330780/
https://ncbi.nlm.nih.gov/pubmed/22241863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00082.2011
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