Chronic ethanol consumption enhances sensitivity to Ca(2+)-mediated opening of the mitochondrial permeability transition pore and increases cyclophilin D in liver

Chronic ethanol consumption increases mitochondrial oxidative stress and sensitivity to form the mitochondrial permeability transition pore (MPTP). The mechanism responsible for increased MPTP sensitivity in ethanol-exposed mitochondria and its relation to mitochondrial Ca(2+) handling is unknown. H...

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Autors principals: King, Adrienne L., Swain, Telisha M., Dickinson, Dale A., Lesort, Mathieu J., Bailey, Shannon M.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2010
Matèries:
Liver and Biliary Tract
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957342/
https://ncbi.nlm.nih.gov/pubmed/20651005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00246.2010
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