Involvement of the mitochondrial permeability transition pore in chronic ethanol-mediated liver injury in mice

Chronic ethanol consumption increases sensitivity of the mitochondrial permeability transition (MPT) pore induction in liver. Ca(2+) promotes MPT pore opening, and genetic ablation of cyclophilin D (CypD) increases the Ca(2+) threshold for the MPT. We used wild-type (WT) and CypD-null (CypD(−/−)) mi...

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Main Authors: King, Adrienne L., Swain, Telisha M., Mao, Zhengkuan, Udoh, Uduak S., Oliva, Claudia R., Betancourt, Angela M., Griguer, Corrine E., Crowe, David R., Lesort, Mathieu, Bailey, Shannon M.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2013
Fag:
Liver and Biliary Tract
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920122/
https://ncbi.nlm.nih.gov/pubmed/24356880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00278.2013
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