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The Conformationally Constrained N-Methanocarba-dT Analog Adopts an Unexpected C4'-exo Sugar Pucker in the Structure of a DNA Hairpin
Incorporation of a bicyclo[3.1.0]hexane scaffold into the nucleoside sugar was devised to lock the embedded cyclopentane ring in conformations that mimic the furanose North and South sugar puckers. To analyze the effects of North-methanocarba-2'-deoxythymidine (N-MCdT) on the conformation of B-...
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| Glavni autori: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3330753/ https://ncbi.nlm.nih.gov/pubmed/22409313 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300215k |
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