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Cyclotides, a novel ultrastable polypeptide scaffold for drug discovery

Cyclotides are a unique and growing family of backbone cyclized peptides that also contain a cystine knot motif built from six conserved cysteine residues. This unique circular backbone topology and knotted arrangement of three disulfide bonds makes them exceptionally stable to thermal, chemical, an...

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Detalhes bibliográficos
Main Authors: Gould, Andrew, Ji, Yanbin, Aboye, Teshome L., Camarero, Julio A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3330703/
https://ncbi.nlm.nih.gov/pubmed/22204428
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