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Polymorphisms in the P2X7 receptor gene are associated with low lumbar spine bone mineral density and accelerated bone loss in post-menopausal women

The P2X7 receptor gene (P2RX7) is highly polymorphic with five previously described loss-of-function (LOF) single-nucleotide polymorphisms (SNP; c.151+1G>T, c.946G>A, c.1096C>G, c.1513A>C and c.1729T>A) and one gain-of-function SNP (c.489C>T). The purpose of this study was to deter...

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Detalhes bibliográficos
Main Authors: Gartland, Alison, Skarratt, Kristen K, Hocking, Lynne J, Parsons, Claire, Stokes, Leanne, Jørgensen, Niklas Rye, Fraser, William D, Reid, David M, Gallagher, James A, Wiley, James S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3330223/
https://ncbi.nlm.nih.gov/pubmed/22234152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2011.245
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