Induction of Strain-Transcending Antibodies Against Group A PfEMP1 Surface Antigens from Virulent Malaria Parasites

Sequence diversity in pathogen antigens is an obstacle to the development of interventions against many infectious diseases. In malaria caused by Plasmodium falciparum, the PfEMP1 family of variant surface antigens encoded by var genes are adhesion molecules that play a pivotal role in malaria patho...

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Main Authors: Ghumra, Ashfaq, Semblat, Jean-Philippe, Ataide, Ricardo, Kifude, Carolyne, Adams, Yvonne, Claessens, Antoine, Anong, Damian N., Bull, Peter C., Fennell, Clare, Arman, Monica, Amambua-Ngwa, Alfred, Walther, Michael, Conway, David J., Kassambara, Lalla, Doumbo, Ogobara K., Raza, Ahmed, Rowe, J. Alexandra
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3330128/
https://ncbi.nlm.nih.gov/pubmed/22532802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002665
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