Roles for ER-associated Degradation (ERAD) and the Novel ER Stress Response Gene, Derlin-3, in the Ischemic Heart

RATIONALE: Stresses, such as ischemia, impair folding of nascent proteins in the rough endoplasmic reticulum (ER), activating the unfolded protein response (UPR), which restores efficient ER protein folding, thus leading to protection from stress. In part, the UPR alleviates ER stress and cell death...

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Main Authors: Belmont, Peter J., Chen, Wenqiong J., San Pedro, Matthew N., Thuerauf, Donna J., Lowe, Nicole Gellings, Gude, Natalie, Hilton, Brett, Wolkowicz, Roland, Sussman, Mark A., Glembotski, Christopher C.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3330119/
https://ncbi.nlm.nih.gov/pubmed/19940266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.203901
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