Complement C3 Deficiency Leads to Accelerated Amyloid β Plaque Deposition and Neurodegeneration and Modulation of the Microglia/Macrophage Phenotype in Amyloid Precursor Protein Transgenic Mice

Complement factor C3 is the central component of the complement system and a key inflammatory protein activated in Alzheimer's disease (AD). Previous studies demonstrated that inhibition of C3 by overexpression of soluble complement receptor-related protein y in an AD mouse model led to reduced...

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Hlavní autoři: Maier, Marcel, Peng, Ying, Jiang, Liying, Seabrook, Timothy J., Carroll, Michael C., Lemere, Cynthia A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329761/
https://ncbi.nlm.nih.gov/pubmed/18562603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0829-08.2008
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