Low Prevalence of TP53 Mutations and MDM2 Amplifications in Pediatric Rhabdomyosarcoma

The tumor suppressor gene TP53 is the most commonly mutated gene in human cancer. The reported prevalence of mutations in rhabdomyosarcoma (RMS) varies widely, with recent larger studies suggesting that TP53 mutations in pediatric RMS may be extremely rare. Overexpression of MDM2 also attenuates p53...

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Main Authors: Ognjanovic, Simona, Martel, Ghyslaine, Manivel, Carlos, Olivier, Magali, Langer, Erica, Hainaut, Pierre
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi Publishing Corporation 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329663/
https://ncbi.nlm.nih.gov/pubmed/22550420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/492086
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