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Mapping the ligand-binding pocket of integrin α5β1 using a gain-of-function approach

Integrin α5β1 is a key receptor for the extracellular matrix protein fibronectin. Antagonists of human α5β1 have therapeutic potential as anti-angiogenic agents in cancer and diseases of the eye. However, the structure of the integrin is unsolved and the atomic basis of fibronectin and antagonist bi...

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Bibliografiske detaljer
Main Authors: Mould, A. Paul, Koper, Ewa, Byron, Adam, Zahn, Grit, Humphries, Martin J.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329623/
https://ncbi.nlm.nih.gov/pubmed/19747169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20090992
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