DUAL FUNCTIONALITY OF THE ANTI-β1 INTEGRIN ANTIBODY, 12G10, EXEMPLIFIES AGONISTIC SIGNALLING FROM THE LIGAND-BINDING POCKET OF INTEGRIN ADHESION RECEPTORS

Although integrins are known to mediate connections between extracellular adhesion molecules and the intracellular actin cytoskeleton, the mechanisms that are responsible for coupling ligand binding to intracellular signalling, for generating diversity in signalling, and for determining the efficacy...

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Main Authors: Humphries, Jonathan D., Schofield, Neil R., Mostafavi-Pour, Zohreh, Green, Linda J., Garratt, Alistair N., Mould, A. Paul, Humphries, Martin J.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2005
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3327468/
https://ncbi.nlm.nih.gov/pubmed/15632175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M411102200
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