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DUAL FUNCTIONALITY OF THE ANTI-β1 INTEGRIN ANTIBODY, 12G10, EXEMPLIFIES AGONISTIC SIGNALLING FROM THE LIGAND-BINDING POCKET OF INTEGRIN ADHESION RECEPTORS

Although integrins are known to mediate connections between extracellular adhesion molecules and the intracellular actin cytoskeleton, the mechanisms that are responsible for coupling ligand binding to intracellular signalling, for generating diversity in signalling, and for determining the efficacy...

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Detalhes bibliográficos
Main Authors: Humphries, Jonathan D., Schofield, Neil R., Mostafavi-Pour, Zohreh, Green, Linda J., Garratt, Alistair N., Mould, A. Paul, Humphries, Martin J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3327468/
https://ncbi.nlm.nih.gov/pubmed/15632175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M411102200
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