MAPK Signaling Determines Anxiety in the Juvenile Mouse Brain but Depression-Like Behavior in Adults

MAP kinase signaling has been implicated in brain development, long-term memory, and the response to antidepressants. Inducible Braf knockout mice, which exhibit protein depletion in principle forebrain neurons, enabled us to unravel a new role of neuronal MAPK signaling for emotional behavior. Braf...

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Main Authors: Wefers, Benedikt, Hitz, Christiane, Hölter, Sabine M., Trümbach, Dietrich, Hansen, Jens, Weber, Peter, Pütz, Benno, Deussing, Jan M., de Angelis, Martin Hrabé, Roenneberg, Till, Zheng, Fang, Alzheimer, Christian, Silva, Alcino, Wurst, Wolfgang, Kühn, Ralf
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329550/
https://ncbi.nlm.nih.gov/pubmed/22529971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035035
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