Deducing corticotropin-releasing hormone receptor type 1 signaling networks from gene expression data by usage of genetic algorithms and graphical Gaussian models

BACKGROUND: Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is a hallmark of complex and multifactorial psychiatric diseases such as anxiety and mood disorders. About 50-60% of patients with major depression show HPA axis dysfunction, i.e. hyperactivity and impaired negative feedback...

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Main Authors: Trümbach, Dietrich, Graf, Cornelia, Pütz, Benno, Kühne, Claudia, Panhuysen, Marcus, Weber, Peter, Holsboer, Florian, Wurst, Wolfgang, Welzl, Gerhard, Deussing, Jan M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3002901/
https://ncbi.nlm.nih.gov/pubmed/21092110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-4-159
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