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Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in β-cells
The circadian clock has been shown to regulate metabolic homeostasis. Mice with a deletion of Bmal1, a key component of the core molecular clock, develop hyperglycemia and hypoinsulinemia suggesting β-cell dysfunction. However, the underlying mechanisms are not fully known. In this study, we investi...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3329519/ https://ncbi.nlm.nih.gov/pubmed/22045262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/isl.3.6.18157 |
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