Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in β-cells

The circadian clock has been shown to regulate metabolic homeostasis. Mice with a deletion of Bmal1, a key component of the core molecular clock, develop hyperglycemia and hypoinsulinemia suggesting β-cell dysfunction. However, the underlying mechanisms are not fully known. In this study, we investi...

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Detaylı Bibliyografya
Asıl Yazarlar: Lee, Jeongkyung, Kim, Mi-Sun, Li, Rongying, Liu, Victoria Y., Fu, Loning, Moore, David D., Ma, Ke, Yechoor, Vijay K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Landes Bioscience 2011
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329519/
https://ncbi.nlm.nih.gov/pubmed/22045262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/isl.3.6.18157
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