Structural selectivity of human SGLT inhibitors

Human Na(+)-d-glucose cotransporter (hSGLT) inhibitors constitute the newest class of diabetes drugs, blocking up to 50% of renal glucose reabsorption in vivo. These drugs have potential for widespread use in the diabetes epidemic, but how they work at a molecular level is poorly understood. Here, w...

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Hlavní autoři: Hummel, Charles S., Lu, Chuan, Liu, Jie, Ghezzi, Chiari, Hirayama, Bruce A., Loo, Donald D. F., Kepe, Vladimir, Barrio, Jorge R., Wright, Ernest M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2012
Témata:
Membrane Transporters, Ion Channels and Pumps
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328840/
https://ncbi.nlm.nih.gov/pubmed/21940664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00328.2011
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