Glucose transport by human renal Na(+)/d-glucose cotransporters SGLT1 and SGLT2

The human Na(+)/d-glucose cotransporter 2 (hSGLT2) is believed to be responsible for the bulk of glucose reabsorption in the kidney proximal convoluted tubule. Since blocking reabsorption increases urinary glucose excretion, hSGLT2 has become a novel drug target for Type 2 diabetes treatment. Glucos...

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Main Authors: Hummel, Charles S., Lu, Chuan, Loo, Donald D. F., Hirayama, Bruce A., Voss, Andrew A., Wright, Ernest M.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2011
Fag:
Membrane Transporters, Ion Channels and Pumps
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023189/
https://ncbi.nlm.nih.gov/pubmed/20980548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00388.2010
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