Temozolomide in aggressive pituitary adenomas and carcinomas

Temozolomide is an alkylating agent used in the treatment of gliomas and, more recently, aggressive pituitary adenomas and carcinomas. Temozolomide methylates DNA and, thereby, has antitumor effects. O(6)-methylguanine-DNA methyltransferase, a DNA repair enzyme, removes the alkylating adducts that a...

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Bibliographic Details
Main Authors: Ortiz, Leon D., Syro, Luis V., Scheithauer, Bernd W., Rotondo, Fabio, Uribe, Humberto, Fadul, Camilo E., Horvath, Eva, Kovacs, Kalman
Format: Artigo
Language:Inglês
Published: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2012
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328813/
https://ncbi.nlm.nih.gov/pubmed/22584716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.6061/clinics/2012(Sup01)20
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