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Temozolomide in aggressive pituitary adenomas and carcinomas
Temozolomide is an alkylating agent used in the treatment of gliomas and, more recently, aggressive pituitary adenomas and carcinomas. Temozolomide methylates DNA and, thereby, has antitumor effects. O(6)-methylguanine-DNA methyltransferase, a DNA repair enzyme, removes the alkylating adducts that a...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3328813/ https://ncbi.nlm.nih.gov/pubmed/22584716 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.6061/clinics/2012(Sup01)20 |
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