Temozolomide in aggressive pituitary adenomas and carcinomas

Temozolomide is an alkylating agent used in the treatment of gliomas and, more recently, aggressive pituitary adenomas and carcinomas. Temozolomide methylates DNA and, thereby, has antitumor effects. O(6)-methylguanine-DNA methyltransferase, a DNA repair enzyme, removes the alkylating adducts that a...

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Bibliografische gegevens
Hoofdauteurs: Ortiz, Leon D., Syro, Luis V., Scheithauer, Bernd W., Rotondo, Fabio, Uribe, Humberto, Fadul, Camilo E., Horvath, Eva, Kovacs, Kalman
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2012
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Review
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328813/
https://ncbi.nlm.nih.gov/pubmed/22584716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.6061/clinics/2012(Sup01)20
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