Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability

Mammalian Bre1 complexes (BRE1A/B (RNF20/40) in humans and Bre1a/b (Rnf20/40) in mice) function similarly to their yeast homolog Bre1 as ubiquitin ligases in monoubiquitination of histone H2B. This ubiquitination facilitates methylation of histone H3 at K4 and K79, and accounts for the roles of Bre1...

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Hauptverfasser: Chernikova, Sophia B., Razorenova, Olga V., Higgins, John P., Sishc, Brock J., Nicolau, Monica, Dorth, Jennifer A., Chernikova, Diana A., Kwok, Shirley, Brooks, James D., Bailey, Susan M., Game, John C., Brown, J. Martin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328627/
https://ncbi.nlm.nih.gov/pubmed/22354749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-2209
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