Deficiency in Bre1 Impairs Homologous Recombination Repair and Cell Cycle Checkpoint Response to Radiation Damage in Mammalian Cells

The pathway involving Bre1-dependent monoubiquitination of histone H2B lysine 123, which leads to Dot1-dependent methylation of histone H3 lysine 79 (H3K79me2), has been implicated in survival after exposure to ionizing radiation in Saccharomyces cerevisiae. We found that depletion of mammalian homo...

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Hlavní autoři: Chernikova, Sophia B., Dorth, Jennifer A., Razorenova, Olga V., Game, John C., Brown, J. Martin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988074/
https://ncbi.nlm.nih.gov/pubmed/20738173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR2184.1
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