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Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis
Cytotoxic T lymphocytes (CTL) induce apoptosis by engaging death receptors or by exocytosis of cytolytic granules containing granzyme (Gzm) proteases and perforin. The lamins, which maintain the structural integrity of the nuclear envelope, are cleaved by caspases during caspase-mediated apoptosis....
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC33284/ https://ncbi.nlm.nih.gov/pubmed/11331782 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.101329598 |
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