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Granzyme A Cleaves a Mitochondrial Complex I Protein to Initiate Caspase-Independent Cell Death

The killer lymphocyte protease granzyme A (GzmA) triggers caspase-independent target cell death with morphological features of apoptosis. We previously showed that GzmA acts directly on mitochondria to generate reactive oxygen species (ROS) and disrupt the transmembrane potential (ΔΨ(m)) but does no...

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Autors principals: Martinvalet, Denis, Dykxhoorn, Derek M., Ferrini, Roger, Lieberman, Judy
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840390/
https://ncbi.nlm.nih.gov/pubmed/18485875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.03.032
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