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BRCA1 regulates microRNA biogenesis via the DROSHA microprocessor complex

MicroRNAs (miRNAs) are noncoding RNAs that function as key posttranscriptional regulators of gene expression. miRNA maturation is controlled by the DROSHA microprocessor complex. However, the detailed mechanism of miRNA biogenesis remains unclear. We show that the tumor suppressor breast cancer 1 (B...

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Detalles Bibliográficos
Main Authors: Kawai, Shinji, Amano, Atsuo
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2012
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328391/
https://ncbi.nlm.nih.gov/pubmed/22492723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201110008
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