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Human telomeres replicate using chromosome-specific, rather than universal, replication programs

Telomeric and adjacent subtelomeric heterochromatin pose significant challenges to the DNA replication machinery. Little is known about how replication progresses through these regions in human cells. Using single molecule analysis of replicated DNA (SMARD), we delineate the replication programs—i.e...

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Main Authors: Drosopoulos, William C., Kosiyatrakul, Settapong T., Yan, Zi, Calderano, Simone G., Schildkraut, Carl L.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328383/
https://ncbi.nlm.nih.gov/pubmed/22508510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201112083
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