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53BP1 deficiency combined with telomere dysfunction activates ATR-dependent DNA damage response
TRF1 protects mammalian telomeres from fusion and fragility. Depletion of TRF1 leads to telomere fusions as well as accumulation of γ-H2AX foci and activation of both the ataxia telangiectasia mutated (ATM)– and the ataxia telangiectasia and Rad3 related (ATR)–mediated deoxyribonucleic acid (DNA) da...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The Rockefeller University Press
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3328378/ https://ncbi.nlm.nih.gov/pubmed/22508511 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201110124 |
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