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Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks
Nonproteolytic ubiquitylation of chromatin surrounding deoxyribonucleic acid double-strand breaks (DSBs), mediated by the RNF8/RNF168 ubiquitin ligases, plays a key role in recruiting repair factors, including 53BP1 and BRCA1, to reestablish genome integrity. In this paper, we show that human RNF169...
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| Huvudupphovsmän: | , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
The Rockefeller University Press
2012
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3328375/ https://ncbi.nlm.nih.gov/pubmed/22492721 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201109100 |
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