RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

Epigenetic pathways can regulate gene expression by controlling and interpreting chromatin modifications. Cancer cells are characterized by altered epigenetic landscapes, and commonly exploit the chromatin regulatory machinery to enforce oncogenic gene expression programs(1). Although chromatin alte...

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Autori principali: Zuber, Johannes, Shi, Junwei, Wang, Eric, Rappaport, Amy R., Herrmann, Harald, Sison, Edward A., Magoon, Daniel, Qi, Jun, Blatt, Katharina, Wunderlich, Mark, Taylor, Meredith J., Johns, Christopher, Chicas, Agustin, Mulloy, James C., Kogan, Scott C., Brown, Patrick, Valent, Peter, Bradner, James E., Lowe, Scott W., Vakoc, Christopher R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328300/
https://ncbi.nlm.nih.gov/pubmed/21814200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10334
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