Biological Role of Aldo–Keto Reductases in Retinoic Acid Biosynthesis and Signaling

Several aldo–keto reductase (AKR) enzymes from subfamilies 1B and 1C show retinaldehyde reductase activity, having low K(m) and k(cat) values. Only AKR1B10 and 1B12, with all-trans-retinaldehyde, and AKR1C3, with 9-cis-retinaldehyde, display high catalytic efficiency. Major structural determinants f...

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Bibliografiske detaljer
Main Authors: Ruiz, F. Xavier, Porté, Sergio, Parés, Xavier, Farrés, Jaume
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Research Foundation 2012
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328219/
https://ncbi.nlm.nih.gov/pubmed/22529810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2012.00058
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