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Human and rodent aldo-keto reductases from the AKR1B subfamily and their specificity with retinaldehyde
NADP(H)-dependent cytosolic aldo-keto reductases (AKR) are mostly monomeric enzymes which fold into a typical (α/β)(8)-barrel structure. Substrate specificity and inhibitor selectivity are determined by interaction with residues located in three highly variable loops (A, B, and C). Based on sequence...
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| Main Authors: | , , , , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2011
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3103653/ https://ncbi.nlm.nih.gov/pubmed/21329680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2011.02.007 |
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