Deuterium-Labeled Phylloquinone Has Tissue-Specific Conversion to Menaquinone-4 among Fischer 344 Male Rats(2)

Phylloquinone (PK) is converted into menaquinone-4 (MK-4) via side chain removal-addition. Stable isotope use is an effective approach to identify the tissue location of this conversion, which is currently unknown. Following a 14-d PK-deficient diet, male Fischer 344 rats (8 mo; n = 15) were fed 1.6...

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Detalhes bibliográficos
Main Authors: Al Rajabi, Ala, Booth, Sarah L., Peterson, James W., Choi, Sang Woon, Suttie, John W., Shea, M. Kyla, Miao, Benchun, Grusak, Michael A., Fu, Xueyan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Nutrition 2012
Assuntos:
Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3327742/
https://ncbi.nlm.nih.gov/pubmed/22437559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3945/jn.111.155804
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