A γ-Tocopherol-Rich Mixture of Tocopherols Maintains Nrf2 Expression in Prostate Tumors of TRAMP Mice via Epigenetic Inhibition of CpG Methylation(2)

Nuclear factor-erythroid 2-related factor 2 (Nrf2) plays a pivotal role in maintaining cellular redox homeostasis and eliminating reactive toxic species. Nrf2 is epigenetically suppressed due to CpG hypermethylation in prostate tumors from the transgenic adenocarcinoma of the mouse prostate (TRAMP)...

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Autori principali: Huang, Ying, Khor, Tin Oo, Shu, Limin, Saw, Constance Lay-Lay, Wu, Tien-Yuan, Suh, Nanjoo, Yang, Chung S., Kong, Ah-Ng Tony
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Nutrition 2012
Soggetti:
Biochemical, Molecular, and Genetic Mechanisms
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3327740/
https://ncbi.nlm.nih.gov/pubmed/22457388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3945/jn.111.153114
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