A γ-Tocopherol-Rich Mixture of Tocopherols Maintains Nrf2 Expression in Prostate Tumors of TRAMP Mice via Epigenetic Inhibition of CpG Methylation(2)

Nuclear factor-erythroid 2-related factor 2 (Nrf2) plays a pivotal role in maintaining cellular redox homeostasis and eliminating reactive toxic species. Nrf2 is epigenetically suppressed due to CpG hypermethylation in prostate tumors from the transgenic adenocarcinoma of the mouse prostate (TRAMP)...

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Main Authors: Huang, Ying, Khor, Tin Oo, Shu, Limin, Saw, Constance Lay-Lay, Wu, Tien-Yuan, Suh, Nanjoo, Yang, Chung S., Kong, Ah-Ng Tony
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Nutrition 2012
Fag:
Biochemical, Molecular, and Genetic Mechanisms
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3327740/
https://ncbi.nlm.nih.gov/pubmed/22457388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3945/jn.111.153114
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