Knock-in of a FLT3/ITD mutation cooperates with a NUP98-HOXD13 fusion to generate acute myeloid leukemia in a mouse model

Constitutive activation of FLT3 by internal tandem duplication (ITD) is one of the most common molecular alterations in acute myeloid leukemia (AML). FLT3/ITD mutations have also been observed in myelodysplastic syndrome patients both before and during progression to AML. Previous work has shown tha...

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Bibliographic Details
Main Authors: Greenblatt, Sarah, Li, Li, Slape, Christopher, Nguyen, Bao, Novak, Rachel, Duffield, Amy, Huso, David, Desiderio, Stephen, Borowitz, Michael J., Aplan, Peter, Small, Donald
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2012
Subjects:
Myeloid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3327463/
https://ncbi.nlm.nih.gov/pubmed/22323452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-10-382283
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