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Inhibition of connective tissue growth factor by small interfering ribonucleic acid prevents increase in extracellular matrix molecules in a rodent model of diabetic retinopathy

PURPOSE: Connective tissue growth factor (CTGF) is a profibrotic factor that induces extracellular matrix (ECM) production and angiogenesis, two processes involved in diabetic retinopathy (DR). In this study, we examined whether insulin therapy or a CTGF-specific small interfering RNA (siRNA) admini...

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Hlavní autoři: Winkler, Jennifer L., Kedees, Mamdouh H., Guz, Yelena, Teitelman, Gladys
Médium: Artigo
Jazyk:Inglês
Vydáno: Molecular Vision 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3327439/
https://ncbi.nlm.nih.gov/pubmed/22511849
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