Biochemical and Morphological Characterization of the AβPP/PS/Tau Triple Transgenic Mouse Model and its Relevance to Sporadic Alzheimer’s Disease

Transgenic (Tg) mouse models of Alzheimer’s disease (AD) have been genetically altered with human familial AD genes driven by powerful promoters. However, a Tg model must accurately mirror the pathogenesis of the human disease, not merely the signature amyloid and/or tau pathology, as such hallmarks...

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Detalhes bibliográficos
Main Authors: Hunter, Jesse M., Bowers, William J., Maarouf, Chera L., Mastrangelo, Michael A., Daugs, Ian D., Kokjohn, Tyler A., Kalback, Walter M., Luehrs, Dean C., Valla, Jon, Beach, Thomas G., Roher, Alex E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3327160/
https://ncbi.nlm.nih.gov/pubmed/21860086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2011-110608
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