NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity

BACKGROUND: Novel prognostic biomarkers and therapeutic strategies are urgently required for malignant melanoma. Ecto-5-prime-nucleotidase (NT5E; CD73) overexpression has been reported in several human cancers. The mechanism(s) underlying deregulated expression and the clinical consequences of chang...

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Detalhes bibliográficos
Main Authors: Wang, H, Lee, S, Nigro, C Lo, Lattanzio, L, Merlano, M, Monteverde, M, Matin, R, Purdie, K, Mladkova, N, Bergamaschi, D, Harwood, C, Syed, N, Szlosarek, P, Briasoulis, E, McHugh, A, Thompson, A, Evans, A, Leigh, I, Fleming, C, Inman, G J, Hatzimichael, E, Proby, C, Crook, T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326678/
https://ncbi.nlm.nih.gov/pubmed/22454080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.95
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