High frequency of complex TP53 mutations in CNS metastases from breast cancer

BACKGROUND: Brain metastasis from breast cancer is usually associated with a poor prognosis and early death. Alteration of p53 may contribute to malignant progression by abrogation of apoptosis induced by oncogene activation and by acquisition of gain-of-function properties, which promote tumour agg...

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Detalhes bibliográficos
Main Authors: Lo Nigro, C, Vivenza, D, Monteverde, M, Lattanzio, L, Gojis, O, Garrone, O, Comino, A, Merlano, M, Quinlan, P R, Syed, N, Purdie, C A, Thompson, A, Palmieri, C, Crook, T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Genetics and Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261685/
https://ncbi.nlm.nih.gov/pubmed/22187033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.464
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