Single Enantiomer of YK-4-279 Demonstrates Specificity in Targeting the Oncogene EWS-FLI1

Oncogenic fusion proteins, such as EWS-FLI1, are excellent therapeutic targets as they are only located within the tumor. However, there are currently no agents targeted toward transcription factors, which are often considered to be ‘undruggable.’ A considerable body of evidence is accruing that ref...

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Autori principali: Barber-Rotenberg, Julie S., Selvanathan, Saravana P., Kong, Yali, Erkizan, Hayriye V., Snyder, Tara M., Hong, S. Peter, Kobs, Christina L., South, Natalie L., Summer, Steven, Monroe, Philip J., Chruszcz, Maksymilian, Dobrev, Veselin, Tosso, Perrer N., Scher, Lauren J., Minor, Wladek, Brown, Milton L., Metallo, Steven J., Üren, Aykut, Toretsky, Jeffrey A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2012
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Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326647/
https://ncbi.nlm.nih.gov/pubmed/22383402
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