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Mechanism of ubiquitylation by dimeric RING ligase RNF4

Mammalian RNF4 is a dimeric RING ubiquitin E3 ligase that ubiquitylates poly-SUMOylated proteins. We found that RNF4 bound ubiquitin-charged UbcH5a tightly but free UbcH5a weakly. To provide insight into the mechanism of RING-mediated ubiquitylation we docked the UbcH5~ubiquitin thioester onto the R...

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Bibliografiset tiedot
Päätekijät: Plechanovová, Anna, Jaffray, Ellis G., McMahon, Stephen A., Johnson, Kenneth A., Navrátilová, Iva, Naismith, James H., Hay, Ronald T.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
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Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326525/
https://ncbi.nlm.nih.gov/pubmed/21857666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2108
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