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RING DOMAIN DIMERIZATION IS ESSENTIAL FOR RNF4 FUNCTION

RNF4 family ubiquitin ligases are RING E3 ligases that regulate the homeostasis of SUMOylated proteins by promoting their ubiquitylation. Here we report that the RING domain of RNF4 forms a stable dimer, and that dimerization is required for ubiquitin transfer. Our data suggests that the stability o...

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Detalhes bibliográficos
Main Authors: Liew, Chu Wai, Sun, Huaiyu, Hunter, Tony, Day, Catherine L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104014/
https://ncbi.nlm.nih.gov/pubmed/20681948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20100957
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