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RING DOMAIN DIMERIZATION IS ESSENTIAL FOR RNF4 FUNCTION
RNF4 family ubiquitin ligases are RING E3 ligases that regulate the homeostasis of SUMOylated proteins by promoting their ubiquitylation. Here we report that the RING domain of RNF4 forms a stable dimer, and that dimerization is required for ubiquitin transfer. Our data suggests that the stability o...
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| Asıl Yazarlar: | , , , |
|---|---|
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2010
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3104014/ https://ncbi.nlm.nih.gov/pubmed/20681948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20100957 |
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