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Spontaneous mutation of the Dock2 gene in Irf5(−/−) mice complicates interpretation of type I interferon production and antibody responses
Genome-wide studies have identified associations between polymorphisms in the IFN regulatory factor-5 (Irf5) gene and a variety of human autoimmune diseases. Its functional role in disease pathogenesis, however, remains unclear, as studies in Irf5(−/−) mice have reached disparate conclusions regardi...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3326475/ https://ncbi.nlm.nih.gov/pubmed/22431588 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118155109 |
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