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N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku

The DNA-dependent protein kinase (DNA-PK) was identified as an activity and as its three component polypeptides 25 and 15 years ago, respectively. It has been exhaustively characterized as being absolutely dependent on free double stranded DNA ends (to which it is directed by its regulatory subunit,...

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Bibliografiske detaljer
Main Authors: Meek, Katheryn, Lees-Miller, Susan P., Modesti, Mauro
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326324/
https://ncbi.nlm.nih.gov/pubmed/22167471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1211
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