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N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku

The DNA-dependent protein kinase (DNA-PK) was identified as an activity and as its three component polypeptides 25 and 15 years ago, respectively. It has been exhaustively characterized as being absolutely dependent on free double stranded DNA ends (to which it is directed by its regulatory subunit,...

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Hlavní autoři: Meek, Katheryn, Lees-Miller, Susan P., Modesti, Mauro
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326324/
https://ncbi.nlm.nih.gov/pubmed/22167471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1211
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