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Telomerase RNA biogenesis involves sequential binding by Sm and Lsm complexes
In most eukaryotes, the progressive loss of chromosome-terminal DNA sequences is counteracted by the enzyme telomerase, a reverse transcriptase that uses part of an RNA subunit as template to synthesize telomeric repeats. Many cancer cells express high telomerase activity and mutations in telomerase...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3326189/ https://ncbi.nlm.nih.gov/pubmed/22446625 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10924 |
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