Deletion of FoxN1 in the Thymic Medullary Epithelium Reduces Peripheral T Cell Responses to Infection and Mimics Changes of Aging

Aging increases susceptibility to infection, in part because thymic involution culminates in reduced naïve T-lymphocyte output. Thymic epithelial cells (TECs) are critical to ensure normal maturation of thymocytes and production of peripheral T cells. The forkhead-class transcription factor, encoded...

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Main Authors: Guo, Jianfei, Feng, Yan, Barnes, Peter, Huang, Fang-Fang, Idell, Steven, Su, Dong-Ming, Shams, Homayoun
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326029/
https://ncbi.nlm.nih.gov/pubmed/22514652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034681
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