Acute Activation of AMP-Activated Protein Kinase Prevents H(2)O(2)-Induced Premature Senescence in Primary Human Keratinocytes

We investigated the effects of AMPK on H(2)O(2)-induced premature senescence in primary human keratinocytes. Incubation with 50 µM H(2)O(2) for 2 h resulted in premature senescence with characteristic increases in senescence-associated ß-galactosidase (SA-gal) staining 3 days later and no changes in...

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Detalhes bibliográficos
Main Authors: Ido, Yasuo, Duranton, Albert, Lan, Fan, Cacicedo, Jose M., Chen, Tai C., Breton, Lionel, Ruderman, Neil B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325987/
https://ncbi.nlm.nih.gov/pubmed/22514710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035092
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