Collaborative Enhancement of Antibody Binding to Distinct PECAM-1 Epitopes Modulates Endothelial Targeting

Antibodies to platelet endothelial cell adhesion molecule-1 (PECAM-1) facilitate targeted drug delivery to endothelial cells by “vascular immunotargeting.” To define the targeting quantitatively, we investigated the endothelial binding of monoclonal antibodies (mAbs) to extracellular epitopes of PEC...

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Bibliografiske detaljer
Main Authors: Chacko, Ann-Marie, Nayak, Madhura, Greineder, Colin F., DeLisser, Horace M., Muzykantov, Vladimir R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325922/
https://ncbi.nlm.nih.gov/pubmed/22514693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034958
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